David St.Clair founded MEDecision in 1988 and has served as the chairman of the board and chief executive officer since 1988. From 1985 until 1988, Mr. St.Clair served as the vice president of GMIS, Inc., which was subsequently acquired by McKesson Corporation. From 1981 until 1985, Mr. St.Clair served as a principal for Hay Associates in its strategic management group. Mr. St.Clair received a B.A.S. in Mechanical Engineering from the University of Pennsylvania and a M.B.A. from Harvard University.

Carl E. Smith joined MEDecision in 2001 as vice president, finance and chief financial officer. In 2002, Mr. Smith became MEDecision's secretary, and he continues to serve in such capacity. In 2004, Mr. Smith was promoted to executive vice president, finance and chief financial officer, and he continues to serve in such capacity. From 1998 until 2001, he served as vice president, finance, and then chief financial officer of Personnel Data Systems, Inc. From 1994 until 1998, he served as senior vice president, finance and administration, of ICT Group, Inc. From 1992 until 1994, Mr. Smith served as controller and then vice president, finance for DNA Plant Technology Corporation. From 1990 until 1992, Mr. Smith served as chief financial officer for Envirosafe Services, Inc. From 1987 until 1989, he served as chief financial officer for Environmental Control Group, Inc. From 1974 until 1987, he served as vice president, controller, and then vice president, finance, of Advanta Corporation. Mr. Smith received a B.S. in Business and Accounting from Pennsylvania State University and is a Certified Public Accountant.

Dr. Andrew Schuyler became MEDecision's executive vice president and chief medical officer in April, 2008. He previously served as executive medical director for Horizon Blue Cross Blue Shield of New Jersey where he was responsible for concurrent medical management, medical policy and appeals, along with process redesign and development of integrated medical management. Prior to joining Horizon in 2004, Dr. Schuyler spent 17 years in managed care administration, including time with the former US Healthcare and Aetna, where he last served as senior medical director. His previous clinical and academic experience includes six years as associate director of a family practice residency training program affiliated with the University of Medicine and Dentistry of New Jersey, and four years in the private practice of family medicine. Dr. Schuyler completed his undergraduate studies at Williams College, earned his medical degree at Cornell University Medical College, and completed a combined Family Medicine and Psychiatry residency/fellowship at Columbia University.